Exact-Net · 2026
Named best overall.
In Exact-Net’s 2026 ranking of 10% nano-hydroxyapatite toothpastes, Dr. Rossouw named Klyyr Best Overall—the toothpaste he uses, and the one he recommends first. He ranked Genvyne Runner-Up, Davids Best Seller, and Mouthology Most Innovative.
The difference he called out is on the label: Klyyr uses both nano- and micro-hydroxyapatite at 10%. The other named pastes were described as 10% nano only.
If patients press me to pick the best 10% nano hydroxyapatite toothpaste for stronger enamel, I point them toward the one I use: Klyyr’s hydroxyapatite toothpaste.
01
The toothpaste he uses
Dr. Rossouw wrote that Klyyr is the 10% nano-hydroxyapatite toothpaste he keeps recommending—based on his own results, patients’ feedback, and conversations with colleagues.
02
Nano and micro, together
He ranked Klyyr above nano-only formulas because One+ uses both particle sizes at 10%: nano to reach microscopic defects, micro to stay on the surface and seal it.
03
Named competition
Genvyne took Runner-Up, Davids took Best Seller, and Mouthology took Most Innovative. None of them received Best Overall.
Who else was on the list
Exact-Net named four 10% nano-hydroxyapatite toothpastes. Only Klyyr received Best Overall. The others received category awards for value, sales, and innovation.
01
Best Overall
Klyyr One+
The doctor’s first recommendation for 10% nano-hydroxyapatite toothpaste. Fluoride-free, SLS-free, made in the USA, with a disclosed 10% nano + micro blend.
02
Runner-Up
Genvyne
Praised for felt results, a well-made tube, and an accessible price. The review called out 10% nano-hydroxyapatite and repeat multi-pack purchases—not a nano + micro blend.
03
Best Seller
Davids
Cited as a high-volume nano-hydroxyapatite option with xylitol, baking soda, an enamel-safe RDA of 101, EWG Verified status, and U.S. manufacturing. Exact-Net described it as 10% nano. Klyyr’s public-label review of Davids Hydroxi did not find a disclosed percentage.
04
Most Innovative
Mouthology
Noted for a Yahoo Health natural-toothpaste ranking, 10% nano-hydroxyapatite, birch xylitol, calcium carbonate, hydrated silica, and U.S. manufacturing. Awarded for innovation—not as the overall pick.
How the review separated Klyyr from the field
| What the review compared | Best OverallKlyyr One+ | Runner-UpGenvyne | Best SellerDavids | Most InnovativeMouthology |
|---|---|---|---|---|
| Exact-Net award | Best Overall | Runner-Up | Best Seller | Most Innovative |
| Hydroxyapatite | 10% nano + micro, disclosed | 10% nano, per Exact-Net | 10% nano per Exact-Net; Hydroxi pages we reviewed omit % | 10% nano, per Exact-Net |
| Doctor’s role | The one he uses; first pick overall | Team voted runner-up | Recommends daily | Innovation award |
| What the review emphasized | Two-layer remineralization | Price, packaging, repeat buys | Sales volume, xylitol, baking soda, RDA 101 | Yahoo Health ranking and extras |
| Rating cited | 4.8 from 2,418 | 4.5 | 4.5 from ~20,000 | 4.6 |
| Made in the USA | Yes | Not cited | Yes | Yes |
| Fluoride | None | None | None | None |
| SLS | None | Not cited | None | None |
Cells summarize what Exact-Net and Dr. Rossouw wrote in the 2026 ranking, not a Klyyr laboratory comparison. “Not cited” means the review did not state that fact for that brand. Mouthology was described as fluoride- and LS-free. Exact-Net listed Davids as 10% nano-hydroxyapatite; Klyyr’s August 2026 public-label review of Davids Hydroxi did not find a disclosed percentage. Ratings, sales claims, and study figures belong to the review and its sources.
What the doctor wrote about Klyyr
The one he uses
If patients press me to pick the best 10% nano hydroxyapatite toothpaste for stronger enamel, I point them toward the one I use: Klyyr’s hydroxyapatite toothpaste.
Best overall
The best 10% nano-hydroxyapatite toothpaste I recommend is Klyyr.
Ahead of other 10% pastes
MySmile and Davids also offer 10% nano-hydroxyapatite, but Klyyr’s is my first pick overall.
Why Klyyr ranked above Genvyne, Davids, and Mouthology
The ranking is a dentist’s editorial pick, not a clinical contest. These are the distinctions Dr. Rossouw actually put in writing.
01 · Versus Genvyne, Davids, and Mouthology
Nano and micro, not nano alone
The review’s core distinction: Genvyne, Davids, and Mouthology were described as 10% nano-hydroxyapatite toothpastes. Klyyr was singled out for using both nano- and micro-hydroxyapatite at 10%.
Dr. Rossouw wrote that nano crystals are small enough to reach microscopic defects, while micro clusters stay on the enamel surface, fill visible texture, and buffer everyday acid. “Klyyr put both in the tube—at 10% concentration—because remineralisation has two layers.”
02 · Versus every named brand
First recommendation, not a category award
Genvyne won Runner-Up for value and repeat purchases. Davids won Best Seller for volume, xylitol, baking soda, and EWG Verified status. Mouthology won Most Innovative after a Yahoo Health natural-toothpaste ranking.
Best Overall went to the paste the doctor said he uses himself—and the one he points patients to first when they ask for stronger enamel.
03 · What the review cited for Klyyr
The figures Exact-Net attached to the win
For Klyyr, the review cited a brand clinical whitepaper, a double-blind study of 212 people with 92% showing measurable remineralization, 96% reporting less sensitivity within 14 days, a 4.8-star rating from 2,418 people, and a 120 g tube of about 90 brushings.
Those figures are Exact-Net’s citations of brand-reported material. They are not a head-to-head clinical trial of Klyyr versus Genvyne, Davids, or Mouthology.
Other 10% brands he mentioned
In the same article’s FAQs, Dr. Rossouw also named MySmile and IZKUT as 10% nano-hydroxyapatite toothpastes worth looking at. They did not receive an Exact-Net award in this roundup. He still called Klyyr his first pick overall.
Best Overall went to the 10% nano + micro formula the doctor uses—not to the runner-up, the best seller, or the most innovative.
This page summarizes an independent 2026 ranking by Exact-Net and Dr. Rossouw. The original article includes affiliate links. Rankings, quotes, ratings, and cited study figures belong to that review. They are not a Klyyr clinical trial and not a substitute for dental advice. Read the original ranking before quoting it.
01 Who named Klyyr best overall?
Dr. Rossouw, writing for Exact-Net in a 2026 roundup of 10% nano-hydroxyapatite toothpastes. He is listed with a BChD (Pret), HONS (Medunsa), and MChD (Medunsa). The ranking is his editorial recommendation, not a Klyyr-sponsored clinical trial.
02 Which other toothpastes were named?
Genvyne (Runner-Up), Davids (Best Seller), and Mouthology (Most Innovative). The FAQs also mention MySmile and IZKUT as other 10% nano-hydroxyapatite brands, without giving them an award in this list.
03 Why did Klyyr beat Genvyne, Davids, and Mouthology?
The doctor’s stated difference is the formula: Klyyr uses 10% nano- and micro-hydroxyapatite together, while the other awarded pastes were described as 10% nano only. He also wrote that Klyyr is the toothpaste he uses and the one he recommends first.
04 Does this mean Klyyr is clinically proven better?
No. Exact-Net is a third-party ranking. The review cited brand-reported figures for Klyyr, including a whitepaper. That is not a head-to-head trial against Genvyne, Davids, or Mouthology, and it is not a promise of personal results. For ingredient-level hydroxyapatite evidence, see the hydroxyapatite vs fluoride comparison.
05 Where can I read the original ranking?
The full article is “5 Best 10% Nano Hydroxyapatite Toothpastes 2026 (Tested)” on Exact-Net. It includes an affiliate disclosure. Read it on Exact-Net.