Particle size

Same mineral · Two size ranges

Nano vs. micro hydroxyapatite.

Quick answer

Nano vs micro hydroxyapatite toothpaste is a particle-size question, not a choice between two different active ingredients. Both are hydroxyapatite. Nano particles are smaller; micro particles are larger.

Published ingredient research examines how smaller particles interact with microscopic surface defects and dentinal tubules, while larger particles remain closer to the tooth surface. Klyyr One+ includes both at a combined 10% concentration. Those studies are not clinical trials of One+.

  • 01

    Nano

    Nano-hydroxyapatite is the same calcium phosphate mineral at a smaller particle-size range. One+ uses a 20–100 nm range as a formulation description, not a clinical measurement of your enamel.

  • 02

    Micro

    Micro-hydroxyapatite is the same mineral at a larger particle-size range. One+ uses a 5–10 micron range as a formulation description.

  • 03

    Together

    One+ combines both in a single 10% blend. Nano and micro are size ranges, not two separate percentage claims stacked on top of each other.

Topic Often sold as Nano-only pastes Klyyr One+ Nano + micro
What it is Hydroxyapatite at a smaller size range Hydroxyapatite at two size ranges, combined 10%
Typical marketing Nano as the sole named form Nano and micro, both named
Published research focus Microscopic defects and tubules in ingredient studies Both size ranges, disclosed on one label
Concentration Often unnamed 10% combined
Fluoride Usually none in this category 0 ppm
One+ particle description Not applicable Nano 20–100 nm · micro 5–10 microns

Nano-only describes a common category pattern, not every competitor. One+ facts are from the product label. Particle-size research is ingredient-level, not a Klyyr clinical result.

What the cited studies actually measured

Particle size is a formulation choice. It does not, by itself, prove a better toothpaste. Keep study type and tested formula in view.

  1. Sensitivity study · small HAp arm · different formula

    Dentin sensitivity

    Hydroxyapatite toothpastes have been studied for dentin sensitivity and interaction with exposed tubules. One cited HAp arm included only ten participants and used a different formula.

    Read the sensitivity study

  2. 18-month adult clinical trial · different formula

    Caries endpoint

    In one 18-month adult study, a 10% HAp toothpaste was non-inferior to 1450 ppm fluoride for the primary caries endpoint. The study tested a different formula.

    Read the 18-month non-inferiority study

  3. In-vitro experiment · different commercial paste

    Surface stains

    An in-vitro experiment measured stain removal after 180 seconds for another commercial HAp toothpaste. That is laboratory data, not a Klyyr whitening result.

    Read the in-vitro stain study

How to choose

A nano + micro paste may fit if

You want both particle-size ranges named on the label, at a disclosed 10%, without treating size language as a clinical guarantee.

A nano-only paste may fit if

You specifically want a nano-only formula, a different flavor system, or a brand your dentist already recommended. Compare the rest of the label, not just the word nano.

Ask a dentist first if

Sensitivity is new, severe, or persistent. Particle-size research is not a diagnosis or a timeline for relief.

The Klyyr One+ formula

One+ is fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% hydroxyapatite

    Combined nano + micro hydroxyapatite, disclosed on the label. Ten percent is not a universal efficacy threshold.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract.

  • 03

    What is not in it

    0 ppm fluoride. No SLS. No artificial dyes. Sodium cocoyl glutamate is the surfactant.

  • 04

    120 g aluminum tube

    4.23 oz, approximately 90 brushings. Aluminum tube, HDPE cap. Recycle where accepted locally.

In short

Nano and micro are sizes of the same mineral. Ask what percentage is disclosed, and whether both sizes are actually in the tube.

01 What is the difference between nano and micro hydroxyapatite?

They are particle-size ranges of the same mineral. Nano is smaller; micro is larger. Published ingredient research studies them at different physical scales.

02 Is nano-hydroxyapatite better than micro?

Not as a blanket rule. Size changes how particles are studied against enamel surfaces and tubules. It does not automatically make one paste better than another.

03 Why does One+ use both nano and micro hydroxyapatite?

To include both size ranges in one disclosed 10% blend. That is a formulation choice, not a claim that One+ has been clinically proven against nano-only pastes.

04 Is nano-hydroxyapatite safe?

One+ is a toothpaste: brush, then spit. Do not swallow toothpaste. For personal safety questions, including use by children, ask a dentist.

05 What percentage of nano vs micro is in One+?

One+ discloses a combined 10% nano + micro blend. It does not split that 10% into two separately marketed percentages. See 10% hydroxyapatite toothpaste.

Read the full FAQ →

Shop

Same formula. Different searches.

One+ is the only product in each collection. Pick the page that matches what you came for.

  1. 01 Nano hydroxyapatite toothpasteNano + micro at a combined 10%.
  2. 02 10% hydroxyapatite toothpasteThe percentage is on the tube.
  3. 03 Toothpaste for enamel10% nano + micro hydroxyapatite.
ONE+
Nano and micro hydroxyapatite, combined at 10%.
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