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SLS-free and fluoride-free toothpaste.
SLS-free and fluoride-free toothpaste leaves out two ingredients that do different jobs: sodium lauryl sulfate, a foaming surfactant, and fluoride, an anticavity active. The pair is common. In Klyyr's comparison of 35 fluoride-free labels, 34 are also SLS-free, so the harder choice is usually the fluoride.
Klyyr One+ contains 0 ppm fluoride and no SLS. It uses sodium cocoyl glutamate as the surfactant and 10% nano + micro hydroxyapatite as the named mineral. If fluoride is your main question, start with the fluoride-free toothpaste guide, which compares those 35 labels. If foam and SLS are the concern, see SLS-free toothpaste.
Fluoride
One+ contains 0 ppm. Fluoride and SLS serve different roles in conventional toothpaste.
SLS
Sodium lauryl sulfate is not in One+. Sodium cocoyl glutamate is the listed surfactant.
Hydroxyapatite
A combined 10% nano + micro blend is the named mineral in the formula.
Lower foam
One+ foams less than a typical SLS paste. Foam volume is not a clinical endpoint.
Two exclusions. Two separate explanations. One fully listed formula.
Formula roles
The mineral and the surfactant are different choices.
One+ names hydroxyapatite as its mineral and sodium cocoyl glutamate as its surfactant. “Fluoride-free” and “SLS-free” should not be collapsed into one claim.
The evidence
What the sources actually say
The evidence, in context.
The adult HAp trial compared another fluoride-free 10% HAp paste with a fluoride paste for one caries endpoint. The SLS review examined recurrent aphthous stomatitis outcomes in people using SLS-free versus SLS-containing dentifrices.
Neither publication tested One+, and neither makes “free from” language a universal health claim.
Different ingredients · Different endpoints · Different formulas
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01
https://pmc.ncbi.nlm.nih.gov/articles/PMC10393266/
Adult HAp-versus-fluoride trial; another toothpaste formula.
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02
https://pubmed.ncbi.nlm.nih.gov/30839136/
Systematic review of SLS-free dentifrice in recurrent aphthous stomatitis.
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03
https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes
ADA overview of fluoride, surfactants, and toothpaste ingredients.
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One+ without fluoride or SLS
0 ppm fluoride, no SLS, 10% nano + micro hydroxyapatite, and all 16 ingredients listed.
One+
Hydroxyapatite toothpaste.
Fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend and a fully listed 16-ingredient formula.
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Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract
01 Are fluoride and SLS the same kind of ingredient?
No. Fluoride compounds are used as anticaries actives. SLS is a surfactant used for foaming and dispersion.
02 What does One+ use instead?
One+ uses 10% nano + micro hydroxyapatite as the named mineral and sodium cocoyl glutamate as the surfactant.
03 Does fluoride-free One+ have the ADA Seal?
No. One+ does not carry the ADA Seal of Acceptance. The ADA requires fluoride in toothpastes accepted for anticaries claims.
04 Is SLS-free toothpaste proven to prevent canker sores?
A systematic review found possible benefit in people with recurrent aphthous stomatitis, but it included four crossover trials and called for stronger research. It did not test One+.