Evidence

What published studies measured · Not a Klyyr trial

Does hydroxyapatite toothpaste work?

Hydroxyapatite toothpaste has real evidence behind it, but less than fluoride. In one 18-month adult study, a 10% hydroxyapatite toothpaste was non-inferior to 1450 ppm fluoride for the primary caries endpoint. Other studies have looked at sensitivity, orthodontic patients, and surface stains. Those studies tested other formulas, not Klyyr One+.

The American Dental Association still recommends fluoride toothpaste as the standard. Its journal's 2025 ethics guidance described nano-hydroxyapatite as likely the second-best option for patients who refuse fluoride, based on the limited studies available.

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01

Cavities: promising, not settled

The strongest adult data is one 18-month non-inferiority trial of a different 10% HAp paste. Fluoride has decades of large trials.

02

Sensitivity: studied, small samples

Hydroxyapatite toothpastes have been studied for dentin sensitivity. One cited HAp arm included only ten participants and used a different formula.

03

Whitening: surface only

An in-vitro experiment measured stain removal for another HAp paste. Hydroxyapatite does not bleach teeth.

Caries endpoint

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One+ hydroxyapatite toothpaste

10% nano + micro hydroxyapatite, 0 ppm fluoride, no SLS, and all 16 ingredients listed.

  • Klyyr One+ natural mint hydroxyapatite toothpaste tube floating with mint leaves and mineral crystals Klyyr One+ 10% hydroxyapatite fluoride-free toothpaste upright with fresh mint leaves in studio

    One+

    $12.95
    $12.95

At a glance

What published studies measured · Not a Klyyr trial

The details, side by side.

Outcome Published research What was studied Takeaway What it means for you
Cavities (adults) 18-month trial: a 10% HAp paste was non-inferior to 1450 ppm fluoride on the primary caries endpoint Encouraging for one formula; not a result for every HAp paste
Orthodontic patients Six-month randomized trial of a microcrystalline HAp paste versus 1,400 ppm fluoride Studied in braces wearers; did not test One+
Sensitivity Dentin sensitivity and tubule studies, some with very small groups Possible benefit; see a dentist for persistent pain
Surface stains In-vitro stain removal for another commercial HAp paste Lab data, not a whitening claim
Safety (EU) 2025 SCCS opinion on a specified rod-shaped nano-HAp at up to 29.5% in toothpaste Applies to that material specification only
Professional position ADA Seal requires fluoride for cavity claims; JADA 2025 calls nHA likely second-best for patients who refuse fluoride Fluoride remains the standard of care

Each row names the study type and tested formula. None of these studies tested Klyyr One+. One+ does not claim to treat, prevent, or reverse any condition.

Sources behind this answer

Keep the study type, endpoint, and tested formula in view when you repeat any of these results.

  1. 18-month adult clinical trial · different formula

    Caries endpoint

    In one 18-month adult study, a 10% HAp toothpaste was non-inferior to 1450 ppm fluoride for the primary caries endpoint. The study tested a different formula.

    Read the 18-month non-inferiority study

  2. Six-month randomized trial · different formula

    Orthodontic patients

    A six-month randomized trial in orthodontic patients compared another microcrystalline HAp toothpaste with a 1,400 ppm fluoride toothpaste. The study did not test One+.

    Read the orthodontic trial

  3. Journal of the American Dental Association · 2025

    Ethics guidance on fluoride refusal

    JADA's ethics column says that if a patient refuses fluoride, nano-hydroxyapatite is "likely the second-best option for them, based on the limited studies available," and that dentists should disagree with aggressively anti-fluoride branding.

    Read the JADA guidance

  4. EU Scientific Committee on Consumer Safety · June 2025

    Hydroxyapatite (nano), Submission IV

    Adopted 26 June 2025, the opinion considers a specified nano-HAp safe at up to 29.5% in toothpaste and 10% in mouthwash. It does not apply to needle-shaped particles.

    Read the 2025 SCCS opinion

Is it right for you?

It may suit you if

You want a fluoride-free daily toothpaste and your dentist agrees that's reasonable for your cavity risk.

Keep fluoride if

You get cavities often, use a prescribed fluoride product, or your dentist recommends fluoride. You can also use both.

It's not a treatment

No toothpaste replaces fillings, cleanings, or an exam for pain, spots, or sensitivity that doesn't settle.

The Klyyr One+ formula

One+ is fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% hydroxyapatite

    Combined nano + micro hydroxyapatite, disclosed on the label. Ten percent is not a universal efficacy threshold.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract.

  • 03

    What is not in it

    0 ppm fluoride. No SLS. No artificial dyes. Sodium cocoyl glutamate is the surfactant.

  • 04

    120 g aluminum tube

    4.23 oz, approximately 90 brushings. Aluminum tube, HDPE cap. Recycle where accepted locally.

In short

Hydroxyapatite toothpaste works well enough in early studies to take seriously, and not well enough yet to replace fluoride as the default. Decide with your dentist.

01 Does hydroxyapatite toothpaste really work?

Published studies of other formulas show promising results for cavities, sensitivity, and surface stains. The evidence is smaller than fluoride's, and no study cited here tested One+.

02 Does hydroxyapatite work as well as fluoride?

One 18-month adult trial found a 10% HAp paste non-inferior to 1450 ppm fluoride on its primary caries endpoint. That is one study of one formula, not proof of equal performance for every paste.

03 Does hydroxyapatite remineralize teeth?

Hydroxyapatite is the same family of mineral as enamel, and studies of other formulas have measured remineralization-related outcomes. One+ does not claim to repair or rebuild teeth.

04 How long does hydroxyapatite toothpaste take to work?

Studies run for weeks to months, and results depend on the formula and outcome. See how long hydroxyapatite toothpaste takes to work.

05 Does the ADA recommend hydroxyapatite toothpaste?

The ADA recommends fluoride toothpaste. Ethics guidance in its journal in 2025 called nano-hydroxyapatite likely the second-best option for patients who refuse fluoride. See do dentists recommend hydroxyapatite toothpaste.

Read the full FAQ →

Keep reading

Related questions.

The answers that usually come next, and the collections they point to.

  1. 01 Hydroxyapatite vs fluorideWhat published studies measured, and how One+ fits.
  2. 02 Do dentists recommend hydroxyapatite toothpaste?The ADA position and JADA's 2025 guidance.
  3. 03 Switching to hydroxyapatite toothpasteThree ways to do it, and what to ask first.
  4. 04 How long does hydroxyapatite take to work?What study timelines look like.
  5. 05 Is hydroxyapatite toothpaste safe?Safety, swallowing, and irritation.
  6. 06 Remineralizing toothpasteHydroxyapatite at a disclosed 10%.
  7. 07 Hydroxyapatite toothpasteThe main One+ shop page.
  8. 08 10% hydroxyapatite toothpasteThe percentage is on the tube.
ONE+
A disclosed 10% nano + micro hydroxyapatite toothpaste.
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