Switching

Ask first · Three options · What changes

Switching to hydroxyapatite toothpaste.

Switching from fluoride to hydroxyapatite toothpaste is an everyday product change, but it's worth asking your dentist first. Fluoride is the most studied cavity-prevention ingredient, and the ADA's journal describes nano-hydroxyapatite as likely the second-best option for people who decline it.

You don't have to switch all at once. Some people replace fluoride entirely, some alternate the two, and some use a paste that contains both. Expect less foam if the new paste is SLS-free, and keep the same amounts and spitting habits as before.

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Ways to switch Full, alternate, or both Ask your dentist about cavity risk first.

01

Ask about your cavity risk first

Frequent cavities, dry mouth, braces, or a prescribed fluoride product are reasons to keep fluoride in your routine.

02

It doesn't have to be all or nothing

Alternating pastes or using a fluoride + hydroxyapatite paste are both common options.

03

The routine stays the same

Two minutes, twice a day, then spit. Hydroxyapatite toothpaste doesn't change the basics.

Ethics guidance on fluoride refusal

Ways to add hydroxyapatite toothpaste to your routine, and what changes
Option	Details What it means	Consider Notes
Full switch	Fluoride-free hydroxyapatite paste at every brushing	Low cavity risk, with your dentist's agreement
Alternate	Fluoride paste at one brushing, hydroxyapatite at the other	For people who want both, or whose dentist wants fluoride
Combined paste	One toothpaste with fluoride and hydroxyapatite	One tube with both ingredients
What feels different	Less foam if the paste is SLS-free; taste varies by brand	One+ foams less and uses peppermint + spearmint
What the label says	Fluoride-free HAp pastes have no Drug Facts panel	One+ is a cosmetic toothpaste with no drug claims
Kids	Ask the child's dentist before switching	Rice-grain under 3, pea-sized for 3–6; spit

General information, not personal dental advice. Toothpastes that combine fluoride and hydroxyapatite are drug products because of the fluoride.

Sources behind this answer

What professional guidance and published research say about moving away from fluoride.

Journal of the American Dental Association · 2025
Ethics guidance on fluoride refusal
JADA's ethics column says that if a patient refuses fluoride, nano-hydroxyapatite is "likely the second-best option for them, based on the limited studies available," and that dentists should disagree with aggressively anti-fluoride branding.
Read the JADA guidance
18-month adult clinical trial · different formula
Caries endpoint
In one 18-month adult study, a 10% HAp toothpaste was non-inferior to 1450 ppm fluoride for the primary caries endpoint. The study tested a different formula.
Read the 18-month non-inferiority study
Klyyr guide
Hydroxyapatite and fluoride together
How people combine a fluoride toothpaste and a hydroxyapatite toothpaste in one routine.
Read the combined-routine guide

Before you switch

Keep fluoride if

You get cavities often, have dry mouth or braces, or use a prescribed fluoride product. Ask your dentist.

Switching a child?

Talk to the child's dentist first, and keep supervising amounts and spitting.

Give it a few weeks

Taste and foam take a few days to get used to. Judge a paste over weeks, not one brushing.

The Klyyr One+ formula

One+ is fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

01
10% hydroxyapatite
Combined nano + micro hydroxyapatite, disclosed on the label. Ten percent is not a universal efficacy threshold.
02
16 listed ingredients
Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract.
03
What is not in it
0 ppm fluoride. No SLS. No artificial dyes. Sodium cocoyl glutamate is the surfactant.
04
120 g aluminum tube
4.23 oz, approximately 90 brushings. Aluminum tube, HDPE cap. Recycle where accepted locally.

In short

Ask first, pick the option that fits your cavity risk, and keep the same two-minute routine.

01 How do I switch from fluoride to hydroxyapatite toothpaste?

Talk to your dentist, then either replace your fluoride paste, alternate the two, or use a paste with both. Keep brushing twice a day for two minutes and spitting.

02 Is it safe to stop using fluoride toothpaste?

That depends on your cavity risk. Fluoride is the most studied cavity-prevention ingredient. See is fluoride-free toothpaste bad.

03 Can I use hydroxyapatite and fluoride toothpaste together?

Yes. Many people alternate them or use a combined paste. See using hydroxyapatite and fluoride together.

04 Will hydroxyapatite toothpaste feel different?

Often, yes. SLS-free pastes like One+ foam less, and flavor and texture vary by brand.

05 Should I switch my child to hydroxyapatite toothpaste?

Ask the child's dentist first. See hydroxyapatite toothpaste for kids.

Read the full FAQ →

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