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Public labels ยท 27 September 2026 ยท No head-to-head trial

Klyyr vs. Crest.

Quick answer

Klyyr vs Crest compares a fluoride-free hydroxyapatite paste with one of the most familiar fluoride drug toothpastes. Crest Pro-Health Advanced is an OTC drug with 0.454% stannous fluoride, labeled for cavities, gingivitis, and sensitivity. It contains no hydroxyapatite.

Klyyr One+ uses a disclosed 10% nano + micro hydroxyapatite blend and 0 ppm fluoride, and makes no drug claims. The inactive ingredients differ too: Crest lists SLS, propylene glycol, carrageenan, saccharin, titanium dioxide, and Blue 1. One+ lists none of them.

Smiling person wearing gold glasses
Klyyr One+ toothpaste standing upright in a studio

Stannous fluoride or hydroxyapatite

  • 01

    Crest carries three drug claims

    Stannous fluoride is labeled as anticavity, antigingivitis, and antisensitivity. One+ is a cosmetic paste with no drug claims.

  • 02

    The inactive lists split sharply

    Crest lists sodium lauryl sulfate, propylene glycol, carrageenan, titanium dioxide, and FD&C Blue 1. One+ contains none of these.

  • 03

    Stannous can stain

    Crest's own label says stannous fluoride may cause surface staining that brushing can prevent. One+ contains no stannous.

Topic Official product information Crest Klyyr One+ One+
Active ingredient 0.454% stannous fluoride (0.16% w/v fluoride ion) None; cosmetic toothpaste
Hydroxyapatite None 10% nano + micro, combined
Labeled uses Cavities, gingivitis, sensitivity No drug claims
SLS Sodium lauryl sulfate None
Glycols and carrageenan Propylene glycol, PEG-6, carrageenan None of these
Colors Titanium dioxide, mica, FD&C Blue 1 No titanium dioxide or dyes
Sweetener Sodium saccharin Sorbitol, xylitol, stevia
Zinc Zinc lactate Zinc citrate
Net contents 3.5 oz / 99 g 4.23 oz / 120 g

Crest details come from the Pro-Health Advanced Drug Facts label on FDA DailyMed, reviewed 27 September 2026. Other Crest pastes use different actives and inactive ingredients. One+ facts come from the current Klyyr label.

Sources reviewed

This is a public-label comparison. The linked official pages are the source of truth for each brand, and neither product has been tested against the other in a clinical trial cited here.

  1. FDA DailyMed Drug Facts label ยท reviewed 27 September 2026

    Crest facts

    The Crest Pro-Health Advanced Drug Facts label lists 0.454% stannous fluoride, with sodium lauryl sulfate, propylene glycol, carrageenan, titanium dioxide, mica, and FD&C Blue 1 among the inactive ingredients.

    Read the current Crest source

  2. Current Klyyr label

    One+ formula facts

    One+ publishes a combined 10% nano + micro hydroxyapatite blend, 16 ingredients, 0 ppm fluoride, no SLS, RDA 62, and a 120 g tube.

    Read the current One+ product page

  3. 50-product label audit ยท August 2026

    Same rules for every brand

    The Klyyr transparency report records a percentage only when a brand or official label states it. Undisclosed values are never filled with retailer guesses.

    Read the audit method and source table

Which one fits your routine?

Crest may fit if

You want a stannous fluoride drug toothpaste with cavity, gum, and sensitivity claims, or your dentist recommended one.

One+ may fit if

You want fluoride-free hydroxyapatite without SLS, propylene glycol, carrageenan, or dyes.

Keep fluoride if

Your dentist recommended fluoride for high cavity risk. A comparison page is not a treatment plan.

The Klyyr One+ formula

One+ is a fluoride-free daily paste with a disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% nano + micro

    One combined 10% hydroxyapatite concentration with both particle-size ranges named on the label.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Peppermint Oil, Spearmint Leaf Oil, Menthol, Sodium Benzoate, and Stevia.

  • 03

    0 ppm fluoride ยท no SLS

    One+ is fluoride-free, peroxide-free, and made without SLS, titanium dioxide, or artificial dyes.

  • 04

    120 g aluminum tube

    4.23 oz with an HDPE cap. Recycle each component where accepted locally.

In short

Crest brings stannous fluoride and three drug claims. One+ brings a 10% hydroxyapatite blend and fewer additives. Choose based on what your dentist says you need.

01 Does Crest toothpaste contain hydroxyapatite?

Crest Pro-Health Advanced lists no hydroxyapatite. Its active is 0.454% stannous fluoride.

02 Is Klyyr better than Crest?

This page does not rank them. Crest is an OTC fluoride drug with labeled cavity, gingivitis, and sensitivity uses. One+ is a fluoride-free hydroxyapatite paste without drug claims.

03 Does Crest Pro-Health contain SLS?

Yes. Sodium lauryl sulfate is listed as an inactive ingredient. One+ uses sodium cocoyl glutamate instead.

04 Why is Crest Pro-Health blue?

The label lists FD&C Blue 1 and mica. One+ contains no artificial dyes.

05 Is hydroxyapatite as good as fluoride?

Some trials found a 10% nano-hydroxyapatite paste performed comparably to fluoride on specific outcomes, but those studies used other formulas. Read the hydroxyapatite vs fluoride guide and follow your dentist's advice on cavity risk.

Read the complete FAQ โ†’

ONE+
Hydroxyapatite instead of fluoride. No SLS, no dyes.
Shop One+ โ€” $12.95 Subscribe & save 25%