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Public labels ยท 27 September 2026 ยท No head-to-head trial

Klyyr vs. Colgate.

Quick answer

Klyyr vs Colgate compares a fluoride-free hydroxyapatite paste with Colgate Total, an ADA-Accepted stannous fluoride drug toothpaste. Colgate Total SF Whitening lists 0.454% stannous fluoride and is labeled for cavities, gingivitis, and sensitivity. It contains no hydroxyapatite.

Klyyr One+ uses a disclosed 10% nano + micro hydroxyapatite blend with 0 ppm fluoride and no drug claims. Colgate lists SLS, two high-intensity sweeteners, PEG-12, and titanium dioxide. One+ uses sodium cocoyl glutamate, xylitol, and stevia and lists none of those.

Smiling person wearing light linen in a tropical setting
Klyyr One+ toothpaste with reflective crystal shapes

The ADA Seal or a fluoride-free label

  • 01

    Colgate carries the ADA Seal

    The Total carton shows ADA Acceptance. One+ does not carry the ADA Seal.

  • 02

    Different enamel strategies

    Colgate relies on stannous fluoride. One+ relies on hydroxyapatite and contains no fluoride.

  • 03

    The additives differ

    Colgate lists SLS, sucralose, saccharin, PEG-12, and titanium dioxide. One+ lists none of them.

Topic Official product information Colgate Klyyr One+ One+
Active ingredient 0.454% stannous fluoride (0.15% w/v fluoride ion) None; cosmetic toothpaste
Hydroxyapatite None 10% nano + micro, combined
Labeled uses Cavities, gingivitis, sensitivity No drug claims
ADA Seal ADA Accepted Not ADA Accepted
Surfactants Sodium lauryl sulfate and cocamidopropyl betaine Sodium cocoyl glutamate
Sweeteners Sucralose, sodium saccharin, sorbitol Sorbitol, xylitol, stevia
Zinc Zinc phosphate Zinc citrate
Titanium dioxide Listed None

Colgate details come from the Colgate Total SF Whitening Paste Drug Facts label on FDA DailyMed, reviewed 27 September 2026. The Whitening Gel and other Total variants differ. One+ facts come from the current Klyyr label.

Sources reviewed

This is a public-label comparison. The linked official pages are the source of truth for each brand, and neither product has been tested against the other in a clinical trial cited here.

  1. FDA DailyMed Drug Facts label ยท reviewed 27 September 2026

    Colgate facts

    The Colgate Total SF Whitening Drug Facts label lists 0.454% stannous fluoride, with sodium lauryl sulfate, cocamidopropyl betaine, zinc phosphate, sucralose, saccharin, and titanium dioxide among the inactive ingredients.

    Read the current Colgate source

  2. Current Klyyr label

    One+ formula facts

    One+ publishes a combined 10% nano + micro hydroxyapatite blend, 16 ingredients, 0 ppm fluoride, no SLS, RDA 62, and a 120 g tube.

    Read the current One+ product page

  3. 50-product label audit ยท August 2026

    Same rules for every brand

    The Klyyr transparency report records a percentage only when a brand or official label states it. Undisclosed values are never filled with retailer guesses.

    Read the audit method and source table

Which one fits your routine?

Colgate may fit if

You want an ADA-Accepted stannous fluoride toothpaste with labeled gum and sensitivity claims.

One+ may fit if

You want fluoride-free hydroxyapatite without SLS, sucralose, saccharin, PEG, or titanium dioxide.

Keep fluoride if

Your dentist recommends fluoride for your cavity risk. Talk to them before switching.

The Klyyr One+ formula

One+ is a fluoride-free daily paste with a disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% nano + micro

    One combined 10% hydroxyapatite concentration with both particle-size ranges named on the label.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Peppermint Oil, Spearmint Leaf Oil, Menthol, Sodium Benzoate, and Stevia.

  • 03

    0 ppm fluoride ยท no SLS

    One+ is fluoride-free, peroxide-free, and made without SLS, titanium dioxide, or artificial dyes.

  • 04

    120 g aluminum tube

    4.23 oz with an HDPE cap. Recycle each component where accepted locally.

In short

Colgate Total has the ADA Seal and three drug claims. One+ has a disclosed 10% hydroxyapatite blend and fewer additives. Those are different kinds of evidence.

01 Does Colgate Total contain hydroxyapatite?

No. The US Colgate Total SF Whitening Paste label lists stannous fluoride as its active and no hydroxyapatite.

02 Is Colgate Total SLS-free?

No. Sodium lauryl sulfate is listed. One+ is SLS-free.

03 Is Klyyr ADA Accepted?

No. One+ does not carry the ADA Seal. Colgate Total SF Whitening does.

04 Is Klyyr better than Colgate?

This page does not claim that. Colgate is a fluoride drug toothpaste with labeled uses; One+ is a fluoride-free hydroxyapatite paste. No head-to-head trial is cited here.

05 What sweeteners are in Colgate Total?

The label lists sucralose, sodium saccharin, and sorbitol. One+ uses sorbitol, xylitol, and stevia.

Read the complete FAQ โ†’

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