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Public labels · 29 August 2026 · No head-to-head trial

Klyyr vs. Apagard.

Quick answer

Klyyr vs Apagard compares a newer transparent-dose paste with the Japanese brand that pioneered medical hydroxyapatite toothpaste. Apagard Premio uses Sangi's proprietary nano Medical Hydroxyapatite and states that Premio contains more than its M-plus and Smokin' formulas, but Sangi does not publish the percentage.

Klyyr One+ publishes a combined 10% nano + micro blend. Both are fluoride-free. Premio lists sodium lauryl sulfate; One+ is SLS-free. Apagard offers decades of brand and regulatory history in Japan, while One+ offers a number shoppers can compare directly.

Smiling person wearing gold glasses
Klyyr One+ toothpaste with reflective mineral-like shapes

Published dose or proprietary heritage

  • 01

    Apagard owns real category history

    Sangi says nano Medical Hydroxyapatite was approved as an anti-caries ingredient in Japan in 1993.

  • 02

    The Premio percentage stays proprietary

    Sangi states that the number is not disclosed. Unofficial 7% or 10% guesses are excluded here.

  • 03

    SLS is a direct label difference

    Premio lists sodium lauryl sulfate. One+ uses sodium cocoyl glutamate and contains no SLS.

Topic Official product information Apagard Klyyr One+ One+
Hydroxyapatite Proprietary nano-mHAP; percentage not disclosed 10% nano + micro, disclosed
Regulatory history Sangi states nano-mHAP was approved for anti-caries use in Japan in 1993 No equivalent Klyyr product approval claim
Fluoride None 0 ppm
SLS Included None
Surfactant Sodium lauryl sulfate Sodium cocoyl glutamate
Flavor Light mint Peppermint + spearmint
Net contents 105 g and 53 g sizes listed 120 g / 4.23 oz
Disclosure approach Relative dose within Apagard range; exact percentage proprietary Exact combined concentration and particle ranges published

Apagard details come from Sangi's official Premio product page and FAQ reviewed 29 August 2026. Japanese regulatory status does not equal an FDA approval for Klyyr or Apagard in the United States. One+ facts come from the current Klyyr label.

Sources reviewed

This is a public-label comparison. The linked official pages are the source of truth for each brand, and neither product has been tested against the other in a clinical trial cited here.

  1. Official competitor page · reviewed 29 August 2026

    Sangi / Apagard facts

    Sangi lists proprietary nano Medical Hydroxyapatite in Apagard Premio, does not disclose the percentage, includes SLS, and states the formula is fluoride-free.

    Read the current Sangi / Apagard source

  2. Current Klyyr label

    One+ formula facts

    One+ publishes a combined 10% nano + micro hydroxyapatite blend, 16 ingredients, 0 ppm fluoride, no SLS, RDA 62, and a 120 g tube.

    Read the current One+ product page

  3. 50-product label audit · August 2026

    Same rules for every brand

    The Klyyr transparency report records a percentage only when a brand or official label states it. Undisclosed values are never filled with retailer guesses.

    Read the audit method and source table

Which one fits your routine?

Apagard may fit if

You value Sangi's long HAp history, specifically want Premio, and are comfortable with SLS and an undisclosed percentage.

One+ may fit if

You want the HAp concentration and both particle ranges published, no SLS, and a larger 120 g tube.

Do not translate approvals

A Japanese ingredient approval is not a Klyyr result and should not be restated as U.S. FDA approval.

The Klyyr One+ formula

One+ is a fluoride-free daily paste with a disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% nano + micro

    One combined 10% hydroxyapatite concentration with both particle-size ranges named on the label.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Peppermint Oil, Spearmint Leaf Oil, Menthol, Sodium Benzoate, and Stevia.

  • 03

    0 ppm fluoride · no SLS

    One+ is fluoride-free, peroxide-free, and made without SLS, titanium dioxide, or artificial dyes.

  • 04

    120 g aluminum tube

    4.23 oz with an HDPE cap. Recycle each component where accepted locally.

In short

Apagard brings category history. One+ brings the exact concentration. Those are different kinds of evidence.

01 How much hydroxyapatite is in Apagard Premio?

Sangi says the percentage in its toothpastes is not disclosed. Premio contains more than M-plus and Smokin', but an exact number is not public.

02 Does Apagard contain fluoride?

Apagard Premio is fluoride-free according to Sangi. One+ is also fluoride-free.

03 Is Apagard SLS-free?

No. The official Premio ingredient list includes sodium lauryl sulfate. One+ is SLS-free.

04 Is Apagard FDA approved?

This page does not make that claim. Sangi discusses Japanese approval of nano Medical Hydroxyapatite as an anti-caries ingredient. Regulatory status is jurisdiction-specific.

05 Is Klyyr better than Apagard?

No head-to-head trial is cited. Klyyr discloses more dose detail and excludes SLS; Apagard has longer category history in Japan.

Read the complete FAQ →

ONE+
The hydroxyapatite percentage is not proprietary.
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