Evidence

Eight claims · Graded by study type

Hydroxyapatite toothpaste benefits, graded.

Quick answer

Hydroxyapatite (HAp) toothpaste is sold on a handful of recurring benefits: cavity protection, enamel remineralization, less sensitivity, whiter-looking teeth, and a fluoride-free routine. The evidence behind them is not equal. Cavity protection has a large randomized trial behind it. Whitening and sensitivity rest mostly on laboratory work and small studies. Gum health has no clinical support we would cite.

This page grades each claim by the kind of study behind it. Every study cited tested a different formula. None is a clinical trial of Klyyr One+.

  • 01

    What hydroxyapatite is

    A calcium phosphate mineral closely related to the mineral in enamel and dentin. In toothpaste it is a cosmetic ingredient, not an FDA-listed anticavity drug.

  • 02

    The strongest result

    One 18-month adult trial found a 10% HAp toothpaste non-inferior to 1450 ppm fluoride on its primary caries endpoint. It tested a different formula.

  • 03

    The weakest claims

    Whitening evidence is mostly laboratory work. Gum health and detox claims have no clinical support we would cite.

Claimed benefit Best evidence found Study type Klyyr's read Strength
Cavity protection 18-month adult RCT: 10% HAp non-inferior to 1450 ppm fluoride on its primary caries endpoint Moderate. One large trial, another formula
Early enamel lesions Lab and in-situ work, plus a six-month orthodontic RCT against 1,400 ppm fluoride Moderate to limited
Dentin sensitivity Small clinical studies; one cited HAp arm had ten people Limited. Promising but small
Whiter-looking teeth 2023 review: 13 lab studies, 6 preliminary clinical trials Limited in people. Not a bleach
Gum health No clinical trial we would cite Not established. No One+ claim
Gentle on enamel Set by the whole paste's abrasivity (RDA), not by HAp alone Check the RDA. One+ publishes 62
Fluoride-free routine A formula fact, not a clinical outcome Fact. One+ is 0 ppm
Swallowing and safety 2025 SCCS opinion on uncoated rod-shaped nano-HAp, within stated limits Context only. Spit, do not swallow

Grades are Klyyr's summary of the cited study types, not a formal evidence rating. Every study tested another formula. One+ facts come from its current label.

What the cited studies actually measured

These are the studies most often behind hydroxyapatite toothpaste claims. Each tested another formula. Keep the study type and endpoint attached when you repeat a result.

  1. 18-month adult clinical trial · different formula

    Caries endpoint

    In one 18-month adult study, a 10% HAp toothpaste was non-inferior to 1450 ppm fluoride for the primary caries endpoint. The study tested a different formula.

    Read the 18-month non-inferiority study

  2. Six-month randomized trial · orthodontic patients

    Enamel around braces

    A six-month randomized trial in orthodontic patients compared another microcrystalline HAp toothpaste with a 1,400 ppm fluoride toothpaste. The study did not test One+.

    Read the orthodontic trial

  3. Sensitivity study · small HAp arm · different formula

    Dentin sensitivity

    Hydroxyapatite toothpastes have been studied for dentin sensitivity and interaction with exposed tubules. One cited HAp arm included only ten participants and used a different formula.

    Read the sensitivity study

  4. Systematic review · 2023 · 17 studies

    Whitening with hydroxyapatite

    The review included 13 in-vitro studies and six preliminary clinical trials. The authors concluded that HAp products whiten teeth and that more clinical trials are needed. Two of the three authors are affiliated with a company that makes HAp toothpaste.

    Read the systematic review

How to choose

If cavities are your main worry

Ask your dentist first. The HAp caries trial is encouraging, but fluoride has decades more data. Do not drop a fluoride routine your dentist prescribed.

If you want fluoride-free with a known dose

Look for the HAp percentage and particle type on the label. One+ lists a combined 10% nano + micro blend. See what 10% means.

If whitening is the goal

HAp is not a bleach. For a shade change, ask your dentist about peroxide or PAP whitening.

The Klyyr One+ formula

One+ is fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend, 16 listed ingredients, peppermint + spearmint, no SLS, and no artificial dyes.

  • 01

    10% hydroxyapatite

    Combined nano + micro hydroxyapatite, disclosed on the label. Ten percent is not a universal efficacy threshold.

  • 02

    16 listed ingredients

    Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract.

  • 03

    What is not in it

    0 ppm fluoride. No SLS. No artificial dyes. Sodium cocoyl glutamate is the surfactant.

  • 04

    120 g aluminum tube

    4.23 oz, approximately 90 brushings. Aluminum tube, HDPE cap. Recycle where accepted locally.

In short

The best-supported benefit of hydroxyapatite toothpaste is cavity protection in adults, from one large trial of a different formula. Sensitivity and whitening claims rest on smaller or laboratory studies. Read every claim with its study type attached.

01 What are the benefits of hydroxyapatite toothpaste?

The best-supported benefit is cavity protection: one 18-month adult trial found a 10% HAp paste non-inferior to 1450 ppm fluoride on its primary caries endpoint. Enamel, sensitivity, and whitening benefits have smaller or laboratory evidence. Every study tested another formula.

02 Is hydroxyapatite toothpaste better than fluoride?

No study shows that for One+. The 18-month trial found non-inferiority, not superiority, on one endpoint for a different paste. Fluoride has far more clinical data. See hydroxyapatite vs fluoride.

03 Does hydroxyapatite toothpaste whiten teeth?

A 2023 systematic review concluded that HAp products whiten teeth, mostly on laboratory evidence plus six preliminary clinical trials. HAp is not a bleach, and One+ makes no whitening claim.

04 Does hydroxyapatite help sensitive teeth?

Hydroxyapatite has been studied for dentin sensitivity in small trials of other formulas. One+ is not a desensitizing drug. See hydroxyapatite for sensitive teeth.

05 Does hydroxyapatite toothpaste have side effects?

The ADA lists flavors, menthol, SLS, and several other ingredients as the usual toothpaste irritants. One+ contains peppermint oil, spearmint oil, and menthol. Stop using any paste that causes swelling, peeling, or a lasting burn, and see a dentist.

Read the full FAQ →

Shop

One tube. Pick the question you came with.

One+ is the only product in each collection. Pick the page that matches what you came for.

  1. 01 Remineralizing toothpasteCalcium phosphate in a daily paste.
  2. 02 10% hydroxyapatite toothpasteThe percentage is on the tube.
  3. 03 Nano hydroxyapatite toothpasteNano + micro, on the label.
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