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Nano + micro hydroxyapatite.
Nano and micro hydroxyapatite toothpaste contains two particle-size ranges of the same calcium-phosphate mineral. In One+, nano is described as 20–100 nanometers and micro as 5–10 micrometers; together they make up a disclosed 10% blend.
Those ranges describe the ingredient specification, not a live measurement of what happens on your teeth. Read the nano vs micro hydroxyapatite guide for the research limits and the difference between size language and clinical evidence.
Same mineral
Nano and micro identify size ranges. They are not two different active ingredients.
1 µm = 1,000 nm
The units differ by a factor of one thousand, so raw numbers need their units attached.
Combined 10%
One+ discloses one total for the nano + micro blend; it does not publish a separate percentage for each range.
Safety needs specs
A safety opinion for one nano-HAp specification cannot be generalized to every shape, coating, or particle range.
Particle-size words are useful only when the range, units, total concentration, and evidence limits stay attached.
Scale diagram
Micrometers and nanometers are different units.
One micrometer equals 1,000 nanometers. The circles illustrate the unit difference, not the exact shape, number, or behavior of particles in One+.
The evidence
What the sources actually say
The evidence, in context.
The 2025 SCCS opinion considered a specified uncoated, rod-shaped nano-HAp material and set explicit dimensional limits. Its conclusion cannot be generalized to needle-shaped or materially different particles.
The review source summarizes how hydroxyapatite is used in oral care. Neither source is a clinical trial of One+.
Specification-level safety opinion · Category review · Not a Klyyr clinical trial
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01
https://health.ec.europa.eu/publications/sccs-scientific-opinion-hydroxyapatite-nano-submission-iv_en
European Commission SCCS final opinion; applies only to the specified nano-HAp material.
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02
https://pmc.ncbi.nlm.nih.gov/articles/PMC8432723/
Review of hydroxyapatite in oral-care products and study models.
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03
https://pmc.ncbi.nlm.nih.gov/articles/PMC10393266/
Adult 10% HAp trial; a different formula, included for category context.
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One+ nano + micro HAp toothpaste
Two disclosed particle-size ranges of hydroxyapatite in one combined 10% formula.
One+
Hydroxyapatite toothpaste.
Fluoride-free toothpaste with a clearly disclosed 10% nano + micro hydroxyapatite blend and a fully listed 16-ingredient formula.
View ingredients
Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract
01 What is the difference between nano and micro hydroxyapatite?
They are different size ranges of hydroxyapatite. One micrometer equals 1,000 nanometers. One+ lists nano at 20–100 nm and micro at 5–10 µm.
02 Why does One+ use both nano and micro HAp?
One+ is formulated with both ranges in one 10% blend. Ingredient research discusses different particle interactions, but One+ has not been clinically tested against a nano-only or micro-only version.
03 Is One+ 10% nano-hydroxyapatite?
It is 10% nano + micro hydroxyapatite combined. Klyyr does not split that total into two separately marketed percentages.
04 Does the European nano-HAp opinion prove every nano toothpaste is safe?
No. The 2025 SCCS opinion applies only to the particle shape, coating status, and size specification described in that opinion. It is not a blanket conclusion for every nano-HAp material or a Klyyr product clearance.